Zetia Handla Online
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Zetia Generiska Köp
Zetia Handla Online LDL is 82? No side effects whatsoever? Zetia Handla Online urushi.co severe hepatic Zetia Handla Online [see Warnings and Precautions 5. Zetia given Zetia Handla Online with a statin is contraindicated in patients with active liver disease or unexplained persistent elevations of hepatic transaminase levels [see Contraindications 4 ; Warnings and Precautions 5.
In the event of an overdose, symptomatic and supportive measures should be employed. Zetia Description Zetia ezetimibe is in a class of lipid-lowering compounds that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. The chemical name of ezetimibe is 1- 4-fluorophenyl -3 R – -4 S – 4-hydroxyphenyl -2-azetidinone.
Its molecular weight is 409. Ezetimibe is a white, crystalline powder that is freely to very soluble in ethanol, methanol, and acetone and practically insoluble in water.
Ezetimibe has a melting point of about 163°C and is Beställ Motrin Piller Zetia Handla Online from circulating lipoproteins, or take up cholesterol absorbed Zetia Handla Online the small intestine. Intestinal Zetia Handla Online is Zetia Handla Online primarily from cholesterol secreted in the bile and from dietary cholesterol. Ezetimibe has a mechanism of action that differs from those of other classes of cholesterol-reducing compounds statins, bile acid sequestrantsfibric acid derivatives, and plant stanols. The molecular target of ezetimibe has been shown to be the sterol transporter, Niemann-Pick C1-Like 1 NPC1L1, which is involved in the intestinal uptake of cholesterol and phytosterols.
Ezetimibe does not inhibit cholesterol synthesis in the liver, or increase bile acid excretion.
Zetia Dosage and Administration
urushi.co HDL-C are associated with the development of atherosclerosis. Epidemiologic studies have established that cardiovascular morbidity and mortality vary directly with the level of total-C and LDL-C and inversely with the level of HDL-C. Like LDL, cholesterol-enriched triglyceride-rich lipoproteins, including very-low-density lipoproteins VLDL, intermediate-density lipoproteins IDL, and remnants, can also promote atherosclerosis.
The independent effect of raising HDL-C or lowering TG on the risk of coronary and cardiovascular morbidity and mortality has not been determined. The effects of ezetimibe given either alone or in addition to a statin or fenofibrate on cardiovascular morbidity and mortality have not been established.
After a single 10-mg dose of Zetia to fasted adults, mean ezetimibe peak plasma concentrations Cmax of 3. There was no substantial deviation from dose urushi.co between 5 and 20 Zetia Handla Online. The absolute bioavailability of ezetimibe cannot be determined, as the compound is virtually insoluble in aqueous media suitable for injection, Zetia Handla Online. Metabolism and Excretion Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugation a phase II reaction with subsequent biliary and renal excretion.
Minimal oxidative metabolism a phase I reaction has been observed in all species evaluated.
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In humans, ezetimibe is rapidly metabolized to ezetimibe-glucuronide. Both ezetimibe and ezetimibe-glucuronide Zetia Handla Online eliminated Zetia Handla Online In linea Tadalafil 20 mg with a half-life of approximately 22 hours for both ezetimibe and ezetimibe-glucuronide. Plasma concentration-time profiles exhibit multiple peaks, Zetia Handla Online, suggesting enterohepatic recycling. After 48 hours, there were no detectable levels of radioactivity in the plasma. Specific Populations Geriatric Patients: Based on a meta-analysis of multiple-dose pharmacokinetic studies, there were no pharmacokinetic differences between Black and Caucasian subjects. Studies in Asian subjects indicated that the pharmacokinetics of ezetimibe were similar to those seen in Caucasian subjects. After a single 10-mg dose of ezetimibe, the mean AUC for total ezetimibe was increased approximately 1.
Zetia Handla Online mean AUC values for total ezetimibe and ezetimibe were increased approximately 3- to 4-fold and 5- to 6-fold, respectively, in patients with moderate Child-Pugh score 7 to 9 Zetia Handla Online severe hepatic Zetia Handla Online Child-Pugh score 10 to 15. In a 14-day, multiple-dose study 10 mg daily in patients with moderate hepatic impairment, the mean AUC values for total ezetimibe and ezetimibe were increased approximately 4-fold on Day 1 and Day 14 compared to healthy subjects. Due to the unknown effects of the increased exposure to ezetimibe in patients with moderate or severe hepatic impairment, Zetia is not recommended in these patients [see Warnings and Precautions 5.