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Rarely and predominantly with intravenous ondansetron, transient ECG changes including QT interval prolongation have been reported.

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Each 4-mg and 8-mg orally disintegrating discount Zofran contains less than 0. Ondansetron was not mutagenic in standard tests for mutagenicity. Published epidemiological studies on the association between ondansetron and fetal outcomes have reported inconsistent findings and have important methodological limitations hindering interpretation see Data, Discount Zofran. The background risk of major birth defects and miscarriage for the indicated population is unknown. Data Human Data Methodological limitations of the epidemiology studies preclude a reliable evaluation of the potential risk of adverse fetal outcomes with the use of ondansetron in pregnancy. Two large retrospective cohort studies of ondansetron use in pregnancy have been published.

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In one study with 1,349 infants born to women who reported the use include the uncertainty of whether women who filled a discount Zofran actually took the medication, Discount Zofran, the concomitant use of other medications or treatments, Discount Zofran, and other unadjusted confounders that may discount Zofran for the study findings. It is unknown whether ondansetron exposure in utero in the cases of cleft palate occurred during the time of palate formation the palate is formed between the 6th and 9th weeks of pregnancy or whether mothers of infants with cleft palate used other medications or had other risk factors for cleft palate in the offspring.

In addition, no discounts Zofran of isolated cleft palate were identified in the aforementioned 2 large retrospective discount Zofran studies. At this time, there is no clear evidence that ondansetron exposure in early pregnancy can cause cleft palate. With the exception of a slight decrease in maternal body weight gain in the rabbits, there were no significant effects of ondansetron on the maternal animals or the development of the offspring. With the exception of a slight reduction in maternal body weight gain, there were no effects upon the pregnant rats and the pre-and postnatal development of their offspring, including reproductive performance of the mated F1 generation.